Selected Publications


Mingde Zheng, Jerry W. Shan, Hao Lin, David I. Shreiber, Jeffrey D. Zahn. "Hydrodynamically Controlled Cell Rotation in an Electroporation Microchip to Circumferentially Deliver Molecules into Single Cells." Microfluidics and Nanofluidics, 20(1), 1-12 (2015). DOI: 10.1007/s10404-015-1691-0.


Yasir Demiryurek, Masoud Nickaeena, Mingde Zheng, Miao Yu, Jeffrey D. Zahn, David I. Shreiber, Hao Lin, Jerry W. Shan. "Transport, resealing, and re-poration dynamics of two-pulse electroporation-mediated molecular delivery." Biochimica et Biophysica Acta (BBA) - Biomembranes Volume 1848, Issue 8, August 2015, Pages 1706–1714. doi:10.1016/j.bbamem.2015.04.007


Mehmet Ag˘irbas¸li, Jeffrey D. Zahn, and Akif U¨ndar. "Biomarkers After Pediatric Heart Surgery." General Methods in Biomarker Research and their Applications, Biomarkers in Disease: Methods, Discoveries and Applications, DOI 10.1007/978-94-007-7696-8_30


Meng-chen Lo , Shuwu Wang, Sagar Singh, Vinod B. Damodaran, Hilton M. Kaplan, Joachim Kohn, David I. Shreiber, Jeffrey D. Zahn. "Coating flexible probes with an ultra fast degrading polymer to aid in tissue insertion.' Biomedical Microdevices, 2015, Volume 17, Number 2, Page 1.


Mehdi Ghodbane, Elizabeth C. Stucky, Tim J. Maguire, Rene S. Schloss, David I. Shreiber, Jeffrey D. Zahn and Martin L. Yarmush. "Development and validation of a microfluidic immunoassay capable of multiplexing parallel samples in microliter volumes." Lab Chip, 2015, 15, 3211-3221.DOI: 10.1039/C5LC00398A



Ghodbane, Mehdi, Anthony Kulesa, H. Yu Henry, Tim J. Maguire, Rene S. Schloss, Rohit Ramachandran, Jeffrey D. Zahn, and Martin L. Yarmush. "Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization." Microfluidics and Nanofluidics (2014): 1-16.


Sadik, Mohamed M., Miao Yu, Mingde Zheng, Jeffrey D. Zahn, Jerry W. Shan, David I. Shreiber, and Hao Lin. "Scaling Relationship and Optimization of Double-Pulse Electroporation." Biophysical journal 106, no. 4 (2014): 801-812.


Ündar, Akif, Shigang Wang, David Palanzo, Bonnie Weaver, Kerem Pekkan, Mehmet Agirbasli, Jeffrey D. Zahn et al. "Outcomes of the Ninth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion." Artificial organs 38, no. 1 (2014): 5-10.



Sasso, L.A., K.Aran, Y.L. Guan, A. Undar, and J.D. Zahn. 2013. Continuous monitoring of inflammation biomarkers during simulated cardiopulmonary bypass using a microfluidic immunoassay device - A pilot study. Artificial Organs, 37(1): E9-E17. PMID: 23305589.


Zhang, Jia, Jeffrey D. Zahn, and Hao Lin. "Transient solution for droplet deformation under electric fields." Physical Review E 87, no. 4 (2013): 043008.


Zhang, Jia, Jeffrey D. Zahn, Wenchang Tan, and Hao Lin. "A transient solution for vesicle electrodeformation and relaxation." Physics of Fluids (1994-present) 25, no. 7 (2013): 071903.



Sasso, L.A., I.H. Johnston, M. Zheng, R.K. Gupte, A. Undar, and J.D. Zahn, 2012. Automated microfluidic processing platform for multiplexed magnetic bead immunoassaysMicrofluidics and Nanofluidics. DOI: 10.1007/s10404-012-0980-0


Morales, M.C., H.Lin, and J.D.Zahn. 2012. Continuous microfluidic DNA and protein trapping and concentration by balancing transverse electrokinetic forces, Lab on a Chip, 12:99-108. PMID: 22045330.



Aran, K., A. Fok, L.A. Sasso, N. Kamdar, Y. Guan, Q. Sun, A Undar, and J.D. Zahn, 2011. Microfiltration Platform for Continuous Blood Plasma Protein Extraction from Whole Blood During Cardiac SurgeryLab on a Chip. 11: 2858-2868.


Masand, S.N., L. Mignone, J.D. Zahn, and D.I. Shreiber, 2011. Nanoporous Membrane-Sealed Microfluidic Devices for Improved Cell ViabilityBiomedical Microdevices. (In Press: DOI: 10.1007/s10544-011-9565-z).


Zhang, J., J.D. Zahn, and H. Lin, 2011, A General Analysis for the Electrohydrodynamic Instability of Stratified Immiscible FluidsJournal of Fluid Mechanics. (In Press DOI: 10.1017/jfm.2011.197).


Langhammer C.G., M.K. Kutzing, V. Luo, J.D. Zahn, and B.L. Firestein, 2011. Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: A comparison of neuronal and myotube extracellular action potentialsBiotechnology Progress. 27:891-895.




Aran, K., L.A. Sasso, N. Kamdar and J.D. Zahn, 2010. Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevicesLab on a Chip. 10: 548-552.


Morales, M.C. and J.D. Zahn, 2010. Droplet enhanced microfluidic-based DNA purification from bacterial lysates via phenol extractionMicrofluidics and Nanofluidics. 9: 1041-1049.


Aran, K., A. Fok, Y. Guan, Q. Sun, J.D. Zahn, and A. Undar, 2010. Differential Immune Activation During Simulated Cardiopulmonary Bypass Procedure Using Freshly Drawn and Week-old Blood — A Pilot StudyArtificial Organs.34(11):1048-1053.


Sasso, L.A., A. Undar, and J.D. Zahn, 2010. Autonomous Magnetically Actuated Continuous Flow Microimmunofluorocytometry AssayMicrofluidics and Nanofluidics. 9(6):1041-1049.


Langhammer, C.G., J.D. Zahn, and B.L. Firestein, 2010. Identification and Quantification of Skeletal Myotubule Contraction and Association In Vitro by Video MicroscopyCytoskeleton. 67(7): 413-424.




Undar, A., L. Pauliks, J.B. Clark, J.D. Zahn, G. Rosenberg, A. Kunselman, Q. Sun, K. Pekkan, K. Saliba, E. Carney, N. Thomas, W. Freeman, K. Vrana, A. El-Banayosy, S.H. Ural, R. Wilson, T.M. Umstead, J. Floras, D.S. Phelps, W. Weiss, A. Snyder, S. Yang, S. Kimatian, S.E. Cyran, V.M. Chinchilli, Y. Guan, A. Rider, N.M. Haines, A. Rogerson, T. Alkan-Bozkaya, A. Akcevin, K. Sun, S. Wang, L. Cun, J.L. Myers, 2009. Penn State Hershey—Center for Pediatric Cardiovascular Research.Artificial Organs. 33(11):883-887.


Miller A. K.C. Lu, S. Wang, T.M. Umstead, W.M. Freeman, Q. Vrana, S. Yang, J.L. Myers, D.S. Phelps, J.D. Zahn, and A. Undar, 2009. Pediatric Cardiopulmonary Bypass Circuits: A Review of the Studies Conducted at the Penn State Pediatric Cardiac Research LaboratoriesThe Journal of the American Society of Extracorporeal Technology. 41(1):50-58.


Harman-Boehm, I., A. Gal, A.M. Raykhman, J.D. Zahn, E. Naidis, Y. Mayzel, 2009. Noninvasive Glucose Monitoring—A Novel ApproachThe Journal of Diabetes Science and Technology. 3(2):253-260.




Hsieh, Y.C. and J.D. Zahn, 2007. On-chip Microdialysis System with Flow Through Glucose Sensing CapabilitiesThe Journal of Diabetes Science and Technology. 1(3):375-383.


Yang. S., A. Undar, and J.D. Zahn, 2007. Continuous Cytometric Bead Processing Within a Microfluidic Device for Bead Based Sensing PlatformsLab on a Chip. 7:588-595.


Hsieh, Y.C. and J.D. Zahn, 2007. On-chip Microdialysis System with Flow Through Sensing ComponentsBiosensors and Bioelectronics. 22:2422-2428.




Yang, S., B. Ji, A. Undar, J.D. Zahn, 2006. Microfluidic Devices for Continuous Blood Plasma Separation and Analysis During Pediatric Cardiopulmony Bypass ProceduresASAIO Journal. 52(6):698-704.


J.D. Zahn and V. Reddy, 2006. Two phase micromixing and analysis using electrohydrodynamic instabilities. Microfluidics and Nanofluidics. 2(5):399-415.


Yang, S., A. Undar, and J.D. Zahn, 2006. A Microfluidic Device for Continuous, Real Time Blood Plasma SeparationLab on a Chip. 6(7):871-880.


Leyton-Mange, J., S. Yang, M.H. Hoskins, R.F. Kunz, J.D. Zahn, C. Dong, 2006. Design of a Side View Particle Imaging Velocimetry Flow System for Cell-Substrate Adhesion StudiesJournal of BioMechanical Engineering. 128(2):271-278.




Yang, S., A. Undar, and J.D. Zahn, 2005. Blood Plasma Separation in Microfluidic Channels Using Flow Rate Control.ASAIO Journal. 51:585-590.


Hsieh, Y.C., and J.D. Zahn, 2005. Glucose Recovery in a Microfluidic Microdialysis BiochipSensors and Actuators B Chemical. 107:649-656.


Reddy, V., and J.D. Zahn, 2005. Interfacial Stabilization of Organic-Aqueous Two Phase Microflows for a Miniaturized DNA Extraction ModuleJournal of Colloid and Interfacial Science. 286:158-165.


Zahn, J.D., Y.C. Hsieh, M. Yang, 2005. Components of an Integrated Microfluidic Device for Continuous Glucose Monitoring with Responsive Insulin DeliveryDiabetes Technology and Therapeutics. 7(3):536-545.


Zahn, J.D., D. Treboutich, and D. Liepmann, 2005. Microdialysis Microneedles for Continous Medical Monitoring.Biomedical Microdevices. 7(1)59-69.




Muthukrishnan, G., C.A. Roberts, Y.C. Chen, J.D. Zahn, and W.O. Hancock, 2004. Patterning Surface-Bound Microtubules Through Reversible DNA HybridizationNanoletters. 4(11):2127-2132.


Yang, M., and J.D. Zahn, 2004. Microneedle Insertion Force Reduction Using Vibratory ActuationBiomedical Microdevices.6(3):177-182.


Zahn, J.D., A. Deshmukh, A.P. Pisano, D. Liepmann, 2004. Continuous On Chip Micropumping for Microneedle Enhanced Drug DeliveryBiomedical Microdevices. 6(3):183-190.


2003 and earlier


Treboutich, D., J.D. Zahn, B. Prabhakarpandian and D. Liepmann, 2003. Modeling of Microfabricated Microneedles for Minimally Invasive Drug Delivery, Sampling and AnalysisBiomedical Microdevices. 5(3):245-251.


Zahn, J.D., N.H. Talbot, D. Liepmann, and A.P. Pisano, 2000. Microfabricated Polysilicon Microneedles for Minimally Invasive Biomedical DevicesBiomedical Microdevices. 2(4):295-303.


Akgun, E., J.D. Zahn, S. Baumes, G. Brown, F. Liang, P.J Romanienko, S. Lewis and M. Jasin, 1997. Palindrome Resolution and Recombination in the mammalian germlineMolecular and Cellular Biology. 17(9):5559-5570.






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