Image Guided Decision Support
System for Pathology

Dorin Comaniciu(1) Peter Meer(1) David Foran(2)

(1) Department of Electrical and Computer Engineering
Rutgers University, Piscataway, NJ 08855, USA

(2)Center for Biomedical Imaging
UMDNJ-Robert Wood Johnson Medical School
Piscataway, NJ 08854, USA

We present an image content-based retrieval system to support decision making in clinical pathology. The Image Guided Decision Support (IGDS) system locates, retrieves, and displays cases which exhibit morphological profiles consistent to the case in question. It uses an image database containing 261 digitized specimens which belong to three classes of lymphoproliferative disorders and a class of healthy leukocytes. The reliability of the central module, the fast color segmenter, makes possible unsupervised on-line analysis of the query image and extraction of the features of interest: shape, area, and texture of the nucleus. The nuclear shape is characterized through similarity invariant Fourier descriptors while the texture analysis is based on a multiresolution simultaneous autoregressive model. The system performance was assessed through ten-fold cross-validated classification and compared with that of a human expert. To facilitate a natural man-machine interface, speech recognition and voice feedback are integrated. Client-server communication is multithreaded, Internet based, and provides access to supporting clinical records and video databases.

Appeared in Machine Vision and Applications, 11, 213-224, 1999.
Preliminary descriptions appeared in 14th Int'l Conference on Pattern Recognition August 1998, Brisbane, Australia, 902-904, and WACV'98 - 4th IEEE Workshop on Applications of Computer Vision, October 1998, Princeton, NJ. 76-87.
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